Prioritizing risk pathways: a novel association approach to searching for disease pathways fusing SNPs and pathways
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چکیده
منابع مشابه
Prioritizing risk pathways: a novel association approach to searching for disease pathways fusing SNPs and pathways
MOTIVATION Complex diseases are generally thought to be under the influence of one or more mutated risk genes as well as genetic and environmental factors. Many traditional methods have been developed to identify susceptibility genes assuming a single-gene disease model ('single-locus methods'). Pathway-based approaches, combined with traditional methods, consider the joint effects of genetic f...
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Genetic factors play a major role in the etiology of many human diseases. Genome-wide experimental methods produce an increasing number of genes associated with such diseases. This chapter introduces data sources, bioinformatics tools, and computational methods for prioritizing disease candidate genes and identifying disease pathways. The main strategy is to examine the similarity among the can...
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MOTIVATION Although genome-wide association studies (GWAS) have found many common genetic variants associated with human diseases, it remains a challenge to elucidate the functional links between associated variants and complex traits. RESULTS We developed a package called eResponseNet by implementing and extending the existing ResponseNet algorithm for prioritizing candidate disease genes th...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2008
ISSN: 1460-2059,1367-4803
DOI: 10.1093/bioinformatics/btn613